In some circles, the word special is used to describe the mentally disabled -- or, for those of generations past, the retarded. I've heard kids tease each other by calling others "special," or describing something as "special" in the same context that they would sarchasticaly use "retarded". Not too long ago (and damnit, I wish I had my camera with me!), I saw a short yellow school bus labeled with the text "A SPECIAL BUS FOR SPECIAL CHILDREN".
I think special is going to be the "gay" of the 2000s; a word with a meaning that will change radically as time goes on, with the old meaning either forgotten or thought of as a quaint anachronism.
Are there any other words that you see as chaving meanings that would change significantly in the next 50 to 100 years?