I am going to throw out the Biggest Little City in the World: Reno (Reno 911 aside). Really, how often do you hear about this place.
As for my hometown Sacramento (yes, I grew up here for almost 13 years of my life), a lot of people know about Sac outside of California. It is the freakin state capital. It is home of the kings and brought the world this great band called Cake. History and railroad buffs alone will keep this place alive damn it.