The closest thing Buffalo might have to a "Jefferson and Alter" is Eggert Road. On Eggert north of the city line (the break in the pavement) is the leafy, well-off Eggertsville neighborhood in Amherst. South of the line is the dense, working/lower-middle predominantly minority Kensington neighborhood in Buffalo, with the middle-class, mostly white Treehaven enclave east of Eggert Road.
A bit west of there: Winspear Avenue and points south are in Buffalo. Mona Drive and points north are in Amherst.
The transition is jarring, but nothing like a cross-Alter journey in Detroit.