As inspired by this thread, I think many of us have visited cities that just don't feel like they belong in the state they're in. The demographics, culture, architecture, landscape, dominant political ideology, and/or other traits give the city and surrounding region a feel like ... well, the license plates you see on the cars are all from out of state/province drivers, or that it's an exclave of another state or part of the country.
(from Forgotten Buffalo)
What are some of those geographically misplaced cities that you've visited? What's the most out of place city in your state?