When I was much younger and attended college (1939)we were allowed to dream and one of the things we dreamed about was Garden Cities for Tomorrow. Core cities of 5,000 people connected to additional towns of like size, each carrying something unique to a larger city of 10,000 or 150,000. The core stayed at 5,000 and the extra load of "whatever" was placed at the perimeter of the core and was accessible to all Ckores via trains or highways. Now, today, the very notion of a Core with perepheral arteries and greenways and local services, seems to be something to be avoided. But I don't know, it sounds like something worth dreaming about, doesn't it? Call it the Genomic Revolution.