Looking at California, there has to be something better than the Hillbillies. I know it's an iconic show, but how about Chips? Ponch is pure California. Maybe Baywatch?
There have been more tv shows set in California than any other state. Probably more than all the other states combined. I propose 'Buffy the Vampire Slayer'
California isn't that homogeneous...
CHiPs, Baywatch are LA/SoCal-centric
Some SF/NorCal alternatives:
The Streets of San Francisco
Full House
Tales of the City
Suddenly Susan
Monk
Silicon Valley
One might even think about Zorro, or Death Valley Days
For
DVD=>Arizona alternative:
All the TV episodes set at in Tombstone, AZ,
including the early "Tombstone Terrotory" series
South Carolina (Charleston only):
Army Wives
Southern Charm
Missouri alternatives:
Petticoat Junction
Green Acres
More California:
Curb Your Enthusiasm (Larry David)
Beverly Hills 90210
Three's Company
Sanford & Son
Room 222
Californication
The O.C.
The Brady Bunch
Veronica Mars
Mannix
Barnaby Jones
The Love Boat
Ozzie and Harriet
Massachusetts alternatives:
Boston Legal
Ally McBeal
The Practice
Sabrina, The Teenage Witch
Dawson's Creek
St. Elsewhere
Illinois alternatives (in Chicago)
The (original) Bob Newhart Show
Chicago Hope
E.R.
Early Edition
Ohio alternatives:
Third Rock From The Sun (Fictional Ohio suburban town)
Family Ties (Michael J. Fox)
Colorado alternative:
Dynasty (Denver)
Only half of I Love Lucy's were in New York! In latest seasons they were all in Westport, CT.
Iconic Manhattan alternatives:
Seinfeld
The Odd Couple
Friends
30 Rock
Sex and The City
Kojak
Barney Miller
The Jeffersons
Good Times
Queens Borough, NYC:
All In The Family
Brooklyn Borough, NYC:
The Honeymooners
Westchester County, NY:
Maude
Where was Amos 'n' Andy supposed to be?
How about Leave it to Beaver?