"Gullah Gullah Island", a children's television show from '94-'98 took place on a fictional barrier island off the coast of South Carolina. One episode even had them visiting the mainland and going to Charleston.
The movie and subsequent TV show of "Jumanji" was based in the fictional town of Brantford, New Hampshire. Also, the mostly terrible Cartoon Network show "Assy McGee" was based in a town called Exeter, New Hampshire. Assy McGee was one of the single worst animated shows ever made and followed a tough guy police detective that is just a pair of legs and an ass.
West Virginia had that show "Buckwild" which was a reality show bout a bunch of drunk sexually promiscuous teenagers. It lasted like one season. You might remember reading in the news several years ago that one of the main guys in the show, Shain Gandee, died of accidental CO poisoning after their SUV became stuck in the mud. They kept it running to keep warm at night and the CO came through a broken back window and killed him and 2 other people.